Preheat oven to 350 degrees F.

Heat a large skillet over medium-high heat. Add pork and cook until almost all the way cooked through, about 5 or 6 minutes. Season pork with chile powder, cumin, onion powder, garlic powder, salt, and pepper. Stir to distribute seasoning evenly.

Add salsa and water to the skillet; stir to combine. Cook for 2 to 3 minutes. Add cheese to skillet, and stir until cheese is melted into the pork, about 1 minute. Remove from heat and set aside.

Line a baking sheet with a Sil-Pat or parchment paper.

Open one can of biscuits and separate each piece of dough. Using your hands, flatten each piece of dough into a flat, circle-ish shape. place dough circles on the prepared baking sheet 1-inch apart.

Spoon a heaping tablespoon of the pork mixture into the middle of each dough circle.

Open the other can of biscuits and repeat step 5, but place each dough circle on top of the pork mixture. Pinch together the edges of each dough pocket to seal in the meat.

Bake for 20 minutes, or until crust is golden. Remove from oven, and serve warm. Top each pocket with salsa verde, and serve with sour cream and cilantro, if desired.